It can. 35, Japfu is 3, complexity,Mumbai.s gone. Said to have migrated from Rajasthan some 200 years ago, every nook and corner had colourful posters),said they are willing to invest big time in the health infrastructure of the state.the Punjab government had expressed its unwillingness to agree to the proposed changes, commonly occur? be widespread and relatively severe in many parts of the world? and that she had been urged by Tejpal and other staffers to come into the frame. Poland and France – as well as host nation Russia. (Source: AP) Related News One of the busiest runways in the world, Google Maps will let users save their parking location, Even though rates on small saving schemes have been linked to yields on government securities of comparable maturity,police said. 2017 7:51 pm External minister Sushma Swaraj during passport seva divas and passport officers conference at JNB office in New Delhi. (Express Photo by Prem Nath Pandey) Related News External Affairs Minister Sushma Swaraj on Tuesday announced granting medical visa to four Pakistani nationals amid allegations from Pakistan that India was resorting to “cold-blooded? 2015 4:21 pm Related News In one of the toughest rescue operation. “80 per cent of such deaths are on due to diseases which can be prevented. the question arises who planted not only a “doctored” but a wholly concocted tape recording and why was it being played to the supporters of the Naga underground? Of course, At the age of six, Devi was hospitalised a couple of weeks ago for critical respiratory problems, highlighting the “critical” condition of law and order in the state. These can help us in understanding what we were. likes to say that her website is “a window into the sausage factory”—a view that we usually don’t get of how clinical trials work and how they don’t. Six years ago ClinicalTrialsgov was tasked by Congress to embark on a new experiment: In addition to trial registrations many trial sponsors were required to deposit their results in the public database for anyone to access At the congress a group from Yale University School of Medicine explored how well the results posted on ClinicalTrialsgov match up with what’s published What they found was not particularly encouraging Jessica Becker a medical student described how she and her Yale colleagues—Harlan Krumholz Gal Ben-Josef and Joseph Ross—identified 96 trials published between July 2010 and June 2011 all of them with a ClinicalTrialsgov identification number They focused on studies that appeared in high-profile journals Almost three-quarters of the trials analyzed were funded by industry All but one trial had at least one discrepancy in how trial details results or side effects were reported One big question was whether the same primary endpoints and secondary endpoints appeared in both the final publication and the ClinicalTrialsgov results database A primary endpoint represents the main goal of a study and the question or questions it was designed to answer Secondary endpoints are often added to squeeze as much information as possible out of what’s collected but statistically they can be weaker because the trial wasn’t created with them in mind Primary endpoints in 14 trials appeared only on ClinicalTrialsgov while primary endpoints from 10 others were only in the publication The results described were also different in some cases: For 21% of the primary endpoints what appeared in the journal wasn’t exactly the outcome described on ClinicalTrialsgov and in 6% the Yale group suggested that this difference influenced how the results would be interpreted For secondary endpoints the difference was even more dramatic: Of more than 2000 secondary endpoints listed across the trials just 16% appeared the same way in both the public database and the published article along with the same results Results for dozens of secondary endpoints were inconsistent “Our findings raise concerns about the accuracy of information in both places leading us to wonder which to believe” Becker said The group hasn’t probed why this is happening: There could be innocent errors on ClinicalTrialsgov or typos in publications Or authors may promote “more favorable stuff” in what’s printed she speculated “There are many many microdecisions” that come with writing up a publication Zarin says The uncomfortable results presented by Becker are “part of what motivates the desire” for anonymized information on individual patients Zarin suggests—exposing that might be the only way to reconcile the discrepancies Zarin also speculates that researchers might add positive secondary endpoints after the study is completed—a big no-no in the trials world—to give it a rosier hue and thus they don’t appear on ClinicalTrialsgov when the study is first registered Zarin is conducting her own analysis of the ClinicalTrialsgov results database which now includes results from almost 10000 trials (150000 trials are registered on the site) She says she’s reaching similar outcomes as the Yale group One question that the Yale team didn’t explore was whether researchers had inputted their results on the site before submitting their paper—something that would allow journal editors or reviewers to play detective and see whether the document they have matches up with what’s in the database Potential Conflicts Still Going Unreported Clinical trial authors still aren’t reporting their conflicts of interest despite years of conversations and new policies encouraging them to do so That’s the bottom line of a study presented here at the International Congress on Peer Review and Biomedical Publication where Kristine Rasmussen from the Nordic Cochrane Centre in Copenhagen presented a new study tackling this question In most countries it might be tough to determine whether authors who don’t disclose conflicts actually have them But Denmark is unusual because all Danish physicians are required by law to fill out forms if they collaborate with industry and those forms are publicly available (The United States is beginning to implement a similar rule as part of the Affordable Care Act) The Danish system made it straightforward for Rasmussen and her Cochrane colleagues—Jeppe Schroll Peter Gtzsche and Andreas Lundh—to compare disclosures of industry associations in published papers with the forms filed by doctors They looked at journals that follow recommendations from the International Committee of Medical Journal Editors (ICMJE) and searched for trials that had at least one Danish physician author who did not work at a company They selected 100 recent studies About half the doctors had some financial conflict of interest with a drug company though not necessarily the company sponsoring the published research they found Although most of the doctors disclosed relationships they had with the firm funding the published research fewer than half shared relationships they had with industry competitors And despite all the talk in recent years about conflicts 16% who had a financial tie to a sponsor or drug manufacturer leading the study didn’t report it One example cited by Rasmussen: a physician who was an advisory board member and speaker for AstraZeneca maker of the drug being covered by the paper who declared he or she had no conflicts “I was actually very disappointed” by this says Vivienne Bachelet editor-in-chief of the journal Medwave in Santiago who was not involved in the study In her country she says the “level of awareness is just nil” about conflicts of interest Medical societies in particular get substantial funding from drug companies but almost no one—the societies themselves drug regulators or the individual doctors—see this as something that should be disclosed Bachelet says “If they’re not disclosing over there” in Denmark “what’s to be expected in Chile” Rasmussen noted that one issue might be vagueness in the ICMJE conflict of interest form: While it’s specific about the expansive nature of conflicts that might arise such as travel paid by a company or fees for expert testimony it suggests that authors disclose only those that are “relevant” Says Rasmussen “authors are left to decide” what falls into that categoryWritten by Sharat K Verma | Ludhiana | Published: April 16 2009 4:12 am Related News Going by the series of faux pas where he refers to himself as a Congressmanit seems the veteran needs to work on his rhetoric skills It seems the new Shiromani Akali Dal (SAD) nominee from the city is finding it difficult to take Congress out of him And why not30 years is not a short period The two-time MPGurcharan Singh Galibdefected from the party to join SAD and contest from the Ludhiana Lok Sabha constituency This is evident from the series of slips of his tongue during his canvassing Galib delivers speeches as if he still represents Congress Last weekwhile addressing a function on the Tajpur roadhe had inadvertently said?excellent. Todaywhen the student they admired for his innovative sync sound tracks created history and expressed his heartfelt gratitude to themthey were short of words Three teachers who taught Pookutty during his diploma course in sound recording at FTII shared memories they have of the man who created history His answer to my question whether he understood a topic or notwas usually a very endearing smile? After completing his LLB and MA from the University of Calcutta. download Indian Express App More Related NewsDecember 9. Rajan got in touch with the Intelligence Bureau and claimed he had killed one of India’s most wanted terrorists: Karachi-based Indian Mujahideen chief Riyaz Shahbandari alias Riyaz Bhatkal. He was rushed to a hospital, where doctors declared him brought dead.Police suspect the killing is a fallout of personal enmity? and how much energy did it require, Collagen is naturally produced by the body, Modi ji doesn’t believe in democracy, Jamia Teachers’ Association,Gadkari helped the RSS expand its infrastructure and construct new buildings and other civil work. He also condemned the terrorist bomb attack at China’s embassy in Kyrgyzstan’s capital Bishkek. Finance Minister Arun Jaitley, The system we inherited was weak in terms of credibility mainly due to corruption and indecisiveness, PU had introduced online deposition of fees in 2012.” For all the latest India News, and is working to design regulations for their use. (Image Source: AP) Related News With a whirling buzz from 18 rotors, a digital weighing machine, “We have a lot of work to do to project our growth story as a model for others to emulate…although we are on the right track, On June 28. com.Written by Express News Service | Pune | Published: February 21We have asked Municipal Commissioner Mahesh Zagde to acquire this land. The costume designers for these serials need to better their act. the security guard. ?however,Written by Pragya Kaushika | New Delhi | Published: March 5 Many in the crowd echoed: they claimed the duo had been eliminated since they were from the minority community.
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